Two sample MR report

Telomere_length against aparc-DKTatlas lh thickness precuneus

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.3139268	0.1171407	0.0140199
Weighted median	23	-0.0612520	0.0602736	0.3095189
Inverse variance weighted	23	-0.0674032	0.0499810	0.1774728
Simple mode	23	-0.0696859	0.1107519	0.5356932
Weighted mode	23	-0.0774203	0.0800806	0.3441627

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	29.16381	21	0.1101239
Inverse variance weighted	36.42309	22	0.0273413

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0151368	0.0066206	0.0327264

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0011949	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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