Two sample MR report

Telomere_length against aparc-DKTatlas lh thickness precentral

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1820021	0.0994051	0.0813414
Weighted median	23	-0.1447353	0.0565009	0.0104177
Inverse variance weighted	23	-0.0967599	0.0388451	0.0127415
Simple mode	23	-0.1390388	0.0910249	0.1408921
Weighted mode	23	-0.1416677	0.0669067	0.0457658

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	17.84245	21	0.6589515
Inverse variance weighted	18.71032	22	0.6631413

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0052339	0.0056181	0.3621317

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000755	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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