Two sample MR report

Telomere_length against aparc-DKTatlas lh thickness posteriorcingulate

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1251666	0.1059507	0.2506636
Weighted median	23	-0.0871051	0.0606770	0.1511293
Inverse variance weighted	23	0.0091662	0.0422389	0.8282016
Simple mode	23	0.1331599	0.1135006	0.2532583
Weighted mode	23	-0.0771135	0.0782803	0.3352880

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	23.85565	21	0.3001053
Inverse variance weighted	26.01088	22	0.2512150

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.008248	0.0059881	0.182892

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007899	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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