Two sample MR report

Telomere_length against aparc-DKTatlas lh thickness postcentral

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.2630541	0.0994045	0.0150997
Weighted median	23	-0.1350673	0.0542234	0.0127404
Inverse variance weighted	23	-0.1116174	0.0388449	0.0040607
Simple mode	23	-0.2104029	0.0886371	0.0267613
Weighted mode	23	-0.1513869	0.0609131	0.0210312

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	17.98260	21	0.6501048
Inverse variance weighted	20.72176	22	0.5379864

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0092983	0.0056182	0.1127864

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008781	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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