Two sample MR report

Telomere_length against aparc-DKTatlas lh thickness pericalcarine

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.3277718	0.1065408	0.0057246
Weighted median	23	-0.1103683	0.0572896	0.0540424
Inverse variance weighted	23	-0.0963311	0.0457536	0.0352536
Simple mode	23	-0.1938693	0.0983236	0.0613423
Weighted mode	23	-0.1139696	0.0607167	0.0738332

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	24.12384	21	0.287097
Inverse variance weighted	30.52178	22	0.106324

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0142105	0.0060215	0.028031

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0011112	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8