Two sample MR report

Telomere_length against aparc-DKTatlas lh thickness parstriangularis

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1263285	0.0994061	0.2176863
Weighted median	23	-0.0606381	0.0572433	0.2894614
Inverse variance weighted	23	-0.0051968	0.0388453	0.8935744
Simple mode	23	-0.0703402	0.0998016	0.4883298
Weighted mode	23	-0.0821772	0.0775762	0.3009510

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	18.80784	21	0.5974656
Inverse variance weighted	20.56032	22	0.5480339

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0074375	0.0056182	0.1997953

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006236	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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