Two sample MR report

Telomere_length against aparc-DKTatlas lh thickness parsorbitalis

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1629324	0.1049592	0.1355224
Weighted median	23	-0.0908049	0.0633195	0.1515507
Inverse variance weighted	23	-0.0459629	0.0414477	0.2674572
Simple mode	23	-0.0963888	0.1246627	0.4476348
Weighted mode	23	-0.1452688	0.0870978	0.1095119

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	23.41208	21	0.3224069
Inverse variance weighted	25.04622	22	0.2948693

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.007182	0.0059321	0.2394622

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008014	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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