Two sample MR report

Telomere_length against aparc-DKTatlas lh thickness parsopercularis

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1493701	0.0994053	0.1478221
Weighted median	23	0.0199033	0.0582775	0.7327068
Inverse variance weighted	23	-0.0176595	0.0388453	0.6493895
Simple mode	23	0.0786202	0.1100199	0.4823708
Weighted mode	23	0.0389052	0.0791317	0.6278357

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	18.08977	21	0.6433164
Inverse variance weighted	20.16177	22	0.5729215

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.008087	0.0056182	0.1647658

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006172	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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