Two sample MR report

Telomere_length against aparc-DKTatlas lh thickness parahippocampal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1571181	0.0994068	0.1289248
Weighted median	23	-0.0704679	0.0556889	0.2057337
Inverse variance weighted	23	-0.0795161	0.0388454	0.0406592
Simple mode	23	-0.0678010	0.0852820	0.4350945
Weighted mode	23	-0.0702456	0.0643030	0.2864699

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	15.34327	21	0.8053421
Inverse variance weighted	16.06251	22	0.8127712

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0047648	0.0056183	0.4059541

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006137	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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