Two sample MR report

Telomere_length against aparc-DKTatlas lh thickness paracentral

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.2598969	0.1223475	0.0456907
Weighted median	23	-0.0350616	0.0642436	0.5852314
Inverse variance weighted	23	-0.0419535	0.0507060	0.4080177
Simple mode	23	0.0439163	0.1120770	0.6989458
Weighted mode	23	0.0163337	0.0923014	0.8611581

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	31.81360	21	0.0611427
Inverse variance weighted	37.48719	22	0.0209018

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0133818	0.0069148	0.066544

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0011712	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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