Two sample MR report

Telomere_length against aparc-DKTatlas lh thickness middletemporal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0996539	0.1155216	0.3980787
Weighted median	23	0.0363868	0.0542404	0.5023202
Inverse variance weighted	23	0.0092649	0.0451933	0.8375665
Simple mode	23	0.0521129	0.0867856	0.5543233
Weighted mode	23	0.0203726	0.0635506	0.7515588

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	28.36092	21	0.1302089
Inverse variance weighted	29.77784	22	0.1239648

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0066875	0.006529	0.3173543

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009039	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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