Two sample MR report

Telomere_length against aparc-DKTatlas lh thickness medialorbitofrontal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0675853	0.1007899	0.5098114
Weighted median	23	0.0156508	0.0557144	0.7787784
Inverse variance weighted	23	0.0020585	0.0389934	0.9578990
Simple mode	23	0.0133949	0.0960849	0.8903973
Weighted mode	23	-0.0052309	0.0620841	0.9336160

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	21.58853	21	0.4235438
Inverse variance weighted	22.16782	22	0.4499105

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0042761	0.0056964	0.4611818

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006718	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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