Two sample MR report

Telomere_length against aparc-DKTatlas lh thickness lingual

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.2247687	0.1157939	0.0657850
Weighted median	23	-0.0569800	0.0588894	0.3332555
Inverse variance weighted	23	-0.0418030	0.0472086	0.3758895
Simple mode	23	-0.0308887	0.1030067	0.7670907
Weighted mode	23	-0.0621540	0.0562861	0.2814156

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	28.49489	21	0.1266658
Inverse variance weighted	32.49323	22	0.0693671

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.011234	0.0065444	0.10077

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010197	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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