Two sample MR report

Telomere_length against aparc-DKTatlas lh thickness lateralorbitofrontal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0708790	0.1163991	0.5491015
Weighted median	23	-0.0350766	0.0583960	0.5480615
Inverse variance weighted	23	-0.0492714	0.0444831	0.2680162
Simple mode	23	-0.2162759	0.1276625	0.1043541
Weighted mode	23	0.0187564	0.0748013	0.8043351

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	28.79371	21	0.1190429
Inverse variance weighted	28.84947	22	0.1492088

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0013267	0.0065786	0.8421156

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000923	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8