Two sample MR report

Telomere_length against aparc-DKTatlas lh thickness lateraloccipital

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.2984383	0.1048152	0.0096479
Weighted median	23	-0.1837720	0.0589003	0.0018082
Inverse variance weighted	23	-0.1282563	0.0428799	0.0027801
Simple mode	23	-0.1306159	0.1138945	0.2637784
Weighted mode	23	-0.1848533	0.0817231	0.0339225

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	23.34940	21	0.3256360
Inverse variance weighted	26.80881	22	0.2185784

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0104493	0.005924	0.0922939

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0011426	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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