Two sample MR report

Telomere_length against aparc-DKTatlas lh thickness isthmuscingulate

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1143633	0.0994060	0.2628843
Weighted median	23	0.0631733	0.0545532	0.2468591
Inverse variance weighted	23	0.0504521	0.0388453	0.1940141
Simple mode	23	0.0247492	0.0970002	0.8009802
Weighted mode	23	0.0862471	0.0634189	0.1876180

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	18.65474	21	0.6072776
Inverse variance weighted	19.14260	22	0.6365072

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0039241	0.0056182	0.4925474

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006312	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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