Two sample MR report

Telomere_length against aparc-DKTatlas lh thickness insula

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0871928	0.1615749	0.5951197
Weighted median	23	0.0079332	0.0615864	0.8975047
Inverse variance weighted	23	-0.0539815	0.0617603	0.3820919
Simple mode	23	0.0498882	0.1090403	0.6517827
Weighted mode	23	0.0252962	0.0639574	0.6962714

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	55.48187	21	6.01e-05
Inverse variance weighted	55.61361	22	9.71e-05

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0020391	0.0091318	0.8254579

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0017434	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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