Two sample MR report

Telomere_length against aparc-DKTatlas lh thickness inferiorparietal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1914634	0.1144248	0.1091071
Weighted median	23	-0.0527022	0.0601689	0.3810817
Inverse variance weighted	23	-0.0643066	0.0451771	0.1546103
Simple mode	23	-0.0420806	0.1081849	0.7010380
Weighted mode	23	-0.1127945	0.0686407	0.1145463

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	27.82606	21	0.1451538
Inverse variance weighted	29.75730	22	0.1244835

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0078074	0.0064671	0.2407533

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009847	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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