Two sample MR report

Telomere_length against aparc-DKTatlas lh thickness fusiform

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0467843	0.1271029	0.7164962
Weighted median	23	-0.0793956	0.0610998	0.1937923
Inverse variance weighted	23	-0.0382094	0.0485329	0.4311134
Simple mode	23	-0.1134768	0.0993862	0.2658228
Weighted mode	23	-0.0887579	0.0674036	0.2014542

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	34.33282	21	0.0333739
Inverse variance weighted	34.34160	22	0.0453315

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0005265	0.0071835	0.942267

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010699	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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