Two sample MR report

Telomere_length against aparc-DKTatlas lh thickness entorhinal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0183067	0.1142601	0.8742396
Weighted median	23	0.0349886	0.0557188	0.5300374
Inverse variance weighted	23	-0.0137408	0.0437197	0.7532984
Simple mode	23	0.0555388	0.0842527	0.5166127
Weighted mode	23	0.0364686	0.0588539	0.5418558

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	27.74419	21	0.1475568
Inverse variance weighted	27.86685	22	0.1801360

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0019677	0.0064577	0.7635889

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008482	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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