Two sample MR report

Telomere_length against aparc-DKTatlas lh thickness cuneus

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.2679284	0.1039606	0.0175702
Weighted median	23	-0.1068789	0.0543673	0.0493140
Inverse variance weighted	23	-0.0535884	0.0441788	0.2251333
Simple mode	23	-0.0647406	0.0885777	0.4725591
Weighted mode	23	-0.0954128	0.0669345	0.1680575

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	22.96889	21	0.3456396
Inverse variance weighted	28.45614	22	0.1610527

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0131604	0.0058756	0.0360488

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009199	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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