Two sample MR report

Telomere_length against aparc-DKTatlas lh thickness caudalmiddlefrontal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1510487	0.0994059	0.1435467
Weighted median	23	-0.0612107	0.0549357	0.2651824
Inverse variance weighted	23	-0.0320371	0.0388454	0.4095235
Simple mode	23	-0.0969188	0.0814387	0.2466980
Weighted mode	23	-0.0694299	0.0613386	0.2698582

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	17.35492	21	0.6893798
Inverse variance weighted	19.04661	22	0.6424485

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0073073	0.0056182	0.2074714

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005977	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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