Two sample MR report

Telomere_length against aparc-DKTatlas lh thickness caudalanteriorcingulate

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1824386	0.0994065	0.0806687
Weighted median	23	-0.0768699	0.0567657	0.1756847
Inverse variance weighted	23	-0.0350744	0.0388456	0.3665690
Simple mode	23	-0.0937007	0.0898593	0.3083883
Weighted mode	23	-0.0962417	0.0612224	0.1302226

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	18.37011	21	0.6254773
Inverse variance weighted	20.96382	22	0.5229754

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0090482	0.0056182	0.1222191

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.00066	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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