Two sample MR report

Telomere_length against aparc-DKTatlas lh area transversetemporal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1912907	0.1048280	0.0822906
Weighted median	23	-0.1178182	0.0579978	0.0422118
Inverse variance weighted	23	-0.0871050	0.0411185	0.0341418
Simple mode	23	-0.1558789	0.0947329	0.1140891
Weighted mode	23	-0.1383515	0.0587836	0.0279412

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	23.35412	21	0.3253921
Inverse variance weighted	24.65061	22	0.3140728

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.006397	0.0059247	0.2925096

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008993	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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