Two sample MR report

Telomere_length against aparc-DKTatlas lh area supramarginal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0226435	0.0994060	0.8220139
Weighted median	23	-0.0739497	0.0547088	0.1764720
Inverse variance weighted	23	-0.0842814	0.0388452	0.0300317
Simple mode	23	-0.1016863	0.0937698	0.2899178
Weighted mode	23	-0.0784222	0.0602217	0.2063086

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	19.38910	21	0.5601950
Inverse variance weighted	20.75462	22	0.5359445

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0065651	0.0056182	0.2556787

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007715	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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