Two sample MR report

Telomere_length against aparc-DKTatlas lh area superiortemporal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0490449	0.1127033	0.6678801
Weighted median	23	-0.0813569	0.0625833	0.1936087
Inverse variance weighted	23	-0.0650870	0.0442516	0.1413344
Simple mode	23	-0.1389998	0.1074791	0.2093323
Weighted mode	23	-0.1297909	0.0827673	0.1311198

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	26.99431	21	0.1710417
Inverse variance weighted	28.55012	22	0.1581585

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0070077	0.0063698	0.2837175

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009502	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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