Two sample MR report

Telomere_length against aparc-DKTatlas lh area superiorparietal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0298106	0.0994057	0.7672109
Weighted median	23	-0.0067929	0.0608557	0.9111220
Inverse variance weighted	23	-0.0028639	0.0388451	0.9412277
Simple mode	23	-0.0389788	0.1099371	0.7262983
Weighted mode	23	-0.0389788	0.0995755	0.6992303

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	20.68855	21	0.4781001
Inverse variance weighted	20.81606	22	0.5321294

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0020062	0.0056182	0.7245864

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006309	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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