Two sample MR report

Telomere_length against aparc-DKTatlas lh area superiorfrontal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0018173	0.1272496	0.9887404
Weighted median	23	-0.0389539	0.0651742	0.5500469
Inverse variance weighted	23	-0.0669568	0.0489389	0.1712588
Simple mode	23	-0.0942896	0.1192466	0.4375537
Weighted mode	23	-0.0491671	0.0789358	0.5397701

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	34.41214	21	0.0327217
Inverse variance weighted	34.91894	22	0.0395072

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0039996	0.0071919	0.5840047

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0011482	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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