Two sample MR report

Telomere_length against aparc-DKTatlas lh area rostralmiddlefrontal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0050755	0.1157222	0.9654311
Weighted median	23	-0.1377682	0.0607054	0.0232407
Inverse variance weighted	23	-0.0759776	0.0446454	0.0887926
Simple mode	23	-0.1259103	0.0988352	0.2159782
Weighted mode	23	-0.1463640	0.0769545	0.0703513

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	28.46052	21	0.1275671
Inverse variance weighted	29.06097	22	0.1431282

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0043534	0.0065404	0.5128999

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009965	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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