Two sample MR report

Telomere_length against aparc-DKTatlas lh area rostralanteriorcingulate

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0028061	0.1095318	0.9798033
Weighted median	23	-0.1195469	0.0603920	0.0477582
Inverse variance weighted	23	-0.0796202	0.0424786	0.0608807
Simple mode	23	-0.0735006	0.1139422	0.5255530
Weighted mode	23	-0.1302970	0.0773863	0.1063733

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	25.4970	21	0.2262806
Inverse variance weighted	26.3085	22	0.2386727

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.005061	0.0061905	0.4227999

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009245	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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