Two sample MR report

Telomere_length against aparc-DKTatlas lh area precuneus

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0831230	0.1332927	0.5395971
Weighted median	23	0.0104957	0.0662801	0.8741776
Inverse variance weighted	23	0.0035128	0.0514901	0.9456081
Simple mode	23	-0.1067555	0.1196151	0.3817882
Weighted mode	23	-0.0016154	0.0757041	0.9831676

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	37.75840	21	0.0137545
Inverse variance weighted	38.65488	22	0.0154520

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0053194	0.0075334	0.4878793

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0011715	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8