Two sample MR report

Telomere_length against aparc-DKTatlas lh area precentral

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1337791	0.0994056	0.1927210
Weighted median	23	-0.0858114	0.0529766	0.1052757
Inverse variance weighted	23	-0.0517435	0.0388453	0.1828471
Simple mode	23	-0.1079900	0.0878821	0.2321274
Weighted mode	23	-0.1002661	0.0632243	0.1270370

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	15.80229	21	0.7806549
Inverse variance weighted	16.60609	22	0.7847110

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.005037	0.0056182	0.3801227

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000557	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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