Two sample MR report

Telomere_length against aparc-DKTatlas lh area posteriorcingulate

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0447854	0.1270827	0.7280421
Weighted median	23	-0.0874981	0.0582903	0.1333365
Inverse variance weighted	23	-0.0606699	0.0485404	0.2113414
Simple mode	23	-0.0480067	0.1002163	0.6366440
Weighted mode	23	-0.0774682	0.0733254	0.3022044

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	34.32125	21	0.0334699
Inverse variance weighted	34.35139	22	0.0452268

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0009753	0.0071824	0.8932798

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0011148	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8