Two sample MR report

Telomere_length against aparc-DKTatlas lh area postcentral

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0794661	0.0994059	0.4330022
Weighted median	23	-0.0160945	0.0571345	0.7781776
Inverse variance weighted	23	-0.0017113	0.0388454	0.9648619
Simple mode	23	-0.0044373	0.1022104	0.9657639
Weighted mode	23	-0.0450192	0.0726923	0.5420716

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	19.49412	21	0.5534746
Inverse variance weighted	20.21622	22	0.5695167

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0047741	0.0056182	0.4050408

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006127	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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