Two sample MR report

Telomere_length against aparc-DKTatlas lh area pericalcarine

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0039957	0.1178897	0.9732825
Weighted median	23	0.0270067	0.0630740	0.6685239
Inverse variance weighted	23	0.0142572	0.0450191	0.7514778
Simple mode	23	-0.0491526	0.1095201	0.6579656
Weighted mode	23	-0.0184577	0.0974015	0.8514371

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	29.53692	21	0.1016962
Inverse variance weighted	29.54950	22	0.1298312

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0006301	0.0066629	0.925559

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008995	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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