Two sample MR report

Telomere_length against aparc-DKTatlas lh area parstriangularis

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1164817	0.1053855	0.2815365
Weighted median	23	-0.0592270	0.0589991	0.3154446
Inverse variance weighted	23	-0.0276872	0.0410301	0.4998015
Simple mode	23	-0.0052571	0.1225007	0.9661562
Weighted mode	23	-0.0912218	0.0862181	0.3015187

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	23.60300	21	0.3126892
Inverse variance weighted	24.54472	22	0.3193377

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.005452	0.0059562	0.3703991

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007592	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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