Two sample MR report

Telomere_length against aparc-DKTatlas lh area parsorbitalis

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0286693	0.1203845	0.8140750
Weighted median	23	0.0483152	0.0634078	0.4460742
Inverse variance weighted	23	0.0442254	0.0459832	0.3361640
Simple mode	23	-0.0429645	0.1182537	0.7198300
Weighted mode	23	0.0836180	0.0855297	0.3388768

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	30.79842	21	0.0770788
Inverse variance weighted	30.82732	22	0.0997035

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0009551	0.0068039	0.8896956

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009734	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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