Two sample MR report

Telomere_length against aparc-DKTatlas lh area parsopercularis

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1855058	0.1068943	0.0973205
Weighted median	23	-0.1072454	0.0589392	0.0688208
Inverse variance weighted	23	-0.0451193	0.0427435	0.2911592
Simple mode	23	-0.1201944	0.1274395	0.3558478
Weighted mode	23	-0.1577450	0.0864861	0.0817767

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	24.28385	21	0.2795092
Inverse variance weighted	26.63785	22	0.2253051

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0086198	0.0060415	0.1683463

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008481	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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