Two sample MR report

Telomere_length against aparc-DKTatlas lh area parahippocampal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0268841	0.1186825	0.8229864
Weighted median	23	0.0166116	0.0556043	0.7651336
Inverse variance weighted	23	-0.0024944	0.0453898	0.9561738
Simple mode	23	0.1230220	0.1026354	0.2434237
Weighted mode	23	-0.0425354	0.0664091	0.5284592

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	29.93464	21	0.0933094
Inverse variance weighted	30.03772	22	0.1175504

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0018038	0.0067076	0.7906141

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009103	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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