Two sample MR report

Telomere_length against aparc-DKTatlas lh area paracentral

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0005728	0.1007434	0.9955171
Weighted median	23	-0.0693825	0.0599105	0.2468224
Inverse variance weighted	23	-0.0211453	0.0388452	0.5862026
Simple mode	23	0.0253730	0.1281949	0.8449213
Weighted mode	23	-0.1066977	0.0889704	0.2431883

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	21.56906	21	0.4246967
Inverse variance weighted	21.61961	22	0.4827799

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0012631	0.0056938	0.8265766

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006641	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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