Two sample MR report

Telomere_length against aparc-DKTatlas lh area middletemporal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0577688	0.1004848	0.5714664
Weighted median	23	-0.0476691	0.0556432	0.3916150
Inverse variance weighted	23	0.0247133	0.0390838	0.5271797
Simple mode	23	-0.0977369	0.1053834	0.3637616
Weighted mode	23	-0.0897744	0.0642743	0.1764248

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	21.45845	21	0.4312699
Inverse variance weighted	22.27103	22	0.4438147

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0050644	0.0056792	0.3826318

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006871	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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