Two sample MR report

Telomere_length against aparc-DKTatlas lh area medialorbitofrontal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1138322	0.1368815	0.4149851
Weighted median	23	0.0245444	0.0604168	0.6845586
Inverse variance weighted	23	-0.0098652	0.0534457	0.8535557
Simple mode	23	-0.1596945	0.1238901	0.2107873
Weighted mode	23	0.0584762	0.0806004	0.4757880

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	39.81916	21	0.0078224
Inverse variance weighted	41.64671	22	0.0068959

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.007595	0.0077362	0.3374021

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0012639	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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