Two sample MR report

Telomere_length against aparc-DKTatlas lh area lingual

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0313569	0.1040770	0.7661600
Weighted median	23	0.0538894	0.0651262	0.4079760
Inverse variance weighted	23	0.0019670	0.0398249	0.9606068
Simple mode	23	0.0831231	0.1330769	0.5386420
Weighted mode	23	0.1036913	0.1221606	0.4051278

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	23.02108	21	0.3428554
Inverse variance weighted	23.12425	22	0.3947421

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0018046	0.0058823	0.7620328

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007008	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8