Two sample MR report

Telomere_length against aparc-DKTatlas lh area lateralorbitofrontal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0203962	0.1296715	0.8765181
Weighted median	23	0.0111727	0.0628512	0.8589082
Inverse variance weighted	23	-0.0115128	0.0495914	0.8164192
Simple mode	23	-0.1377715	0.1155079	0.2456752
Weighted mode	23	0.0038985	0.0717528	0.9571613

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	35.73455	21	0.0234142
Inverse variance weighted	35.85616	22	0.0314613

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0019592	0.0073287	0.7918218

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010891	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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