Two sample MR report

Telomere_length against aparc-DKTatlas lh area lateraloccipital

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0552941	0.1413760	0.6996529
Weighted median	23	0.0242290	0.0622122	0.6969381
Inverse variance weighted	23	0.0764620	0.0540098	0.1568620
Simple mode	23	0.0318668	0.1112527	0.7772241
Weighted mode	23	0.0271569	0.0781955	0.7316702

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	42.47774	21	0.0036626
Inverse variance weighted	42.53126	22	0.0053869

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0012997	0.0079902	0.8723404

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0014061	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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