Two sample MR report

Telomere_length against aparc-DKTatlas lh area isthmuscingulate

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1156075	0.1232462	0.3588975
Weighted median	23	0.0517680	0.0564653	0.3592415
Inverse variance weighted	23	0.0066196	0.0483370	0.8910727
Simple mode	23	0.0247332	0.1144490	0.8308957
Weighted mode	23	0.0367818	0.0686532	0.5974986

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	32.28069	21	0.0548270
Inverse variance weighted	34.06503	22	0.0483815

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0075047	0.0069656	0.2935236

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010331	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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