Two sample MR report

Telomere_length against aparc-DKTatlas lh area insula

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1436634	0.1445435	0.3315811
Weighted median	23	-0.0345038	0.0599164	0.5647064
Inverse variance weighted	23	-0.0143605	0.0564125	0.7990609
Simple mode	23	-0.0210900	0.1307748	0.8733527
Weighted mode	23	-0.0828607	0.0686857	0.2404862

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	44.40240	21	0.0020732
Inverse variance weighted	46.39937	22	0.0017563

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0079392	0.0081692	0.3421945

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0014101	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8