Two sample MR report

Telomere_length against aparc-DKTatlas lh area inferiortemporal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0660046	0.1164771	0.5769423
Weighted median	23	-0.0656811	0.0591369	0.2667134
Inverse variance weighted	23	-0.0627979	0.0444713	0.1579211
Simple mode	23	-0.0968203	0.1147454	0.4078722
Weighted mode	23	-0.0937062	0.0898044	0.3080718

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	28.83407	21	0.1180425
Inverse variance weighted	28.83530	22	0.1496234

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0001969	0.0065831	0.9764216

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009529	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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