Two sample MR report

Telomere_length against aparc-DKTatlas lh area inferiorparietal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1251883	0.1160130	0.2927871
Weighted median	23	0.0293489	0.0565180	0.6035630
Inverse variance weighted	23	0.0570655	0.0472641	0.2272881
Simple mode	23	0.0327897	0.1044682	0.7565750
Weighted mode	23	0.0120855	0.0574846	0.8354169

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	28.60248	21	0.1238770
Inverse variance weighted	32.56971	22	0.0681886

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0111903	0.0065568	0.1026278

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010523	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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