Two sample MR report

Telomere_length against aparc-DKTatlas lh area fusiform

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0686292	0.0994054	0.4975050
Weighted median	23	0.0530776	0.0583814	0.3632691
Inverse variance weighted	23	-0.0143742	0.0388452	0.7113552
Simple mode	23	0.0540615	0.1111841	0.6316097
Weighted mode	23	0.0773244	0.0844680	0.3698919

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	20.65549	21	0.4801485
Inverse variance weighted	21.47837	22	0.4913664

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0050964	0.0056182	0.3746315

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000655	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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